The server has reached its limit for processing requests from your host.\n451 Please try again later. It generally appears when your server simultaneous incoming connections limit exceeded. So to resolve the issue please increase the incomming connection limit in server’s exim.conf file.
By default simultaneous incoming connections limit : 100
#vi /etc/exim.conf
smtp_accept_max = 200
#service exim restart
Now issue should be resolved.

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